Correspondence, notebooks, reports, legal documents, contracts, research data, publications, all of which relate to Goldstine's professional contributions as a professor of mathematics at the University of Chicago, 1936-1939 and University of Michigan, 1939-1950; United States Army, Lieutenant Colonel in charge of the governement development of the ENIAC and EDVAC computers, 1941-1945; Institute for Advanced Study, Assistant Project Director for electronic computer project, 1946-1958; International Business Machines Corporation: Director of Mathematical Sciences, Research 1958-1960; Director Mathematical Sciences Department, IBM Research, 1960-1965; Director of Scientific Development, Data Processing Division, 1965-1967; Consultant to Director of Research, 1967-1969; IBM Fellow, 1969-1984; American Philosophical Society, Executive Officer, 1984-1997. Dr. Goldstine's contributions to the development of the computer are documented in the collection, especially in relation to his work with John von Neumann.

Britton Chance (1913-2010) was a biochemist and biophysicist as well as a pioneer in the field of biomedical optics. Chance received his Ph.D. in Physical Chemistry from the University of Pennsylvania in 1940 and his Ph.D. in Biology and Physiology from Cambridge University in 1942. Over the course of his nearly eight decade career, Chance was dedicated to the application and transfer of basic scientific research and technology to clinical medicine. The Britton Chance Papers contain correspondence, research notes, experimental data, publication materials, and photographs stemming from Chance's life as a biochemist, biophysicist, and yachtsman. The collection is broken up into fifteen series that document every aspect of his scientific work.